IBIS (Tyrer-Cuzick) Breast Cancer Risk Evaluation Web Batch Tool (v8)
About
The program assumes that there is a gene predisposing to breast cancer in addition to the BRCA1/2 genes. The woman's family history is used to calculate the likelihood of her carrying an adverse gene, which in turn affects her likelihood of developing breast cancer. The risks of developing breast cancer for the general population were taken from data on the first breast cancer diagnosis (ICD-10 code C50) in Thames Cancer Registry area (UK) between 2005-2009. The risk from family history (caused by the adverse genes) is modelled to fit the results in "Familial Breast and Ovarian Cancer: A Swedish Population-based Register Study, Anderson H et al., American Journal of Epidemiology 2000, 152: 1154-1163". The risk from other classical factors including age at first child and benign disease are combined with familial risk. The latest version of the model (v8) incorporates mammographic density.
The version on this website allows the user to run a batch of risk assessments by uploading an input file, and then receiving an output text file with the results. It is in beta testing, and output should be verified by the user against the most recent version from the IBIS trials website.
To use the tool you need to upload your input file, decide whether or not to adjust for competing mortality, then click the download button. This will run the algorithm, then return results. You will need to wait for the algorithm to finish before the file will be generated, so be patient particularly if your input file is large.
How to generate the input file
Please follow the instructions in the input file guide to prepare your input file before uploading. Note that this software runs on a server with limited memory, so it is unlikely to run if the batch is for more than 10,000 people. If you need to run it on a larger batch, split up your cohort into sub-batches, and run each.
Run Tyrer-Cuzick Batch Here
How to interpret the output
The output provided is the same as from the Windows tool, available from the IBIS trials website. Each line in the output file is a proband. The values returned are separated by commars. These are: ID (as provided in the input file), then individual's 1,2,3,4,5,10,20,lifetime-risk, Prob not BRCA, Prob BRCA1, Prob BRCA2, and then the same for the general population of the same age in the model.
Contact
For further information contact: wiph-tyrercuzick@qmul.ac.uk
This tool is provided for research purposes only and no responsibility is accepted for clinical decisions arising from its use. Commercial use requires a license, for further information please email TyrerCuzick@cancer.org.uk. Page last updated: 17/Apr/2026